Flugal 50mg Capsule

✔️ Uses of Flugal 50mg Capsule

• Treatment of Fungal Infections

✔️ How does Flugal 50mg Capsule work?

Flugal 50mg Capsule works by inhibiting the action of an enzyme called ergosterol, which is vital for the fungal cell membrane's integrity. By doing so, it increases the cell membrane's permeability, effectively stopping fungal growth. This mechanism is beneficial in treating and preventing various fungal infections.

✔️ Side Effects of Flugal 50mg Capsule

• Headache
• Nausea and vomiting
• Stomach pain
• Diarrhea
• Indigestion
• Hair loss
• Heartburn
• Swelling of face, lips, eyelids, tongue, hands and feet
• Dizziness
• Drowsiness

✔️ Quick Suggestions:

• Flugal 50mg Capsule is used to treat various fungal infections such as candida infection.
• You should not take this medicine if you are allergic to fluconazole or other similar antifungal medication.
• Take this medicine as prescribed by your doctor at a fixed time to gain optimal benefits.
• Always complete the entire course of the treatment with a Flugal 50mg Capsule, as incomplete treatment may result in treatment failure and an increased risk of re-infection.
• This medicine should not be used by pregnant women unless needed or in case of a life-threatening infection.
• Talk to your doctor if you are allergic to fluconazole or any other ingredient of it.

✔️ Indication of Flugal 50mg Capsule

Flugal 50mg Capsule is prescribed for the treatment of various fungal infections, including hepatosplenic candidiasis and other Candida infections, cryptococcal infections, and secondary prophylaxis for cryptococcal meningitis in individuals with AIDS. It is also used as antifungal prophylaxis in allogeneic bone marrow transplant recipients. Additionally, Fazol 100Mg Tablet is indicated for oral or vaginal candidiasis that is unresponsive to nystatin or clotrimazole, as well as non-life-threatening Candida infections such as cystitis and esophagitis. It is an alternative treatment for those unable to tolerate amphotericin B.

✔️ Pharmacology

Fluconazole is an antifungal medication that works by inhibiting the activity of the cytochrome P450 enzyme, which is essential for the synthesis of ergosterol, a vital component of the fungal cell membrane. By interfering with ergosterol synthesis, Fluconazole disrupts the formation of the cell membrane in susceptible fungi, leading to their growth inhibition and ultimately causing their death. It is effective against a wide range of fungal species, including B. dermatitidis, Candida spp., C. immitis, C. neoformans, Epidermophyton spp., H. capsulatum, Micosporum spp., and Trichophyton spp.

✔️ Dosage & Administration of Flugal 50mg Capsule

Adult Dose:

• Oropharyngeal Candidiasis: 200 mg PO on Day 1, THEN 100 mg qDay. Treatment should be continued for at least 2 weeks to decrease the likelihood of relapse.
• Esophageal Candidiasis: 200 mg PO on Day 1, THEN 100 mg qDay; doses up to 400 mg/day may be used based on the patient's response. Treat for a minimum of 3 weeks and for at least 2 weeks following resolution of symptoms.
• Vaginal Candidiasis; Candidal Balanitis: Uncomplicated: 150 mg PO as a single dose. Complicated: 150 mg PO q72hr for 3 doses. Recurrent: 150 mg PO quay for 10-14 days followed by 150 mg once weekly for 6 months.
• Cutaneous Candidiasis; Dermatophytosis; Pityriasis Versicolor: 50 mg once daily for up to 6 weeks.
• Systemic Candidiasis; Cryptococcal Infections: Initially, 400 mg, followed by 200-400 mg once daily. Treatment duration is based on clinical and mycological response but is usually at least 6-8 weeks in cryptococcal meningitis. To prevent relapse after a primary course of treatment for acute cryptococcal meningitis in AIDS patients: 100-200 mg daily.
• Prophylaxis of Fungal Infections in Immunocompromised Patients: 50-400 mg daily. Prophylaxis in patients undergoing bone marrow transplantation: The recommended daily dosage is 400 mg, once daily. Patients who are anticipated to have severe granulocytopenia (less than 500 neutrophils per cu mm) should start Fluconazole Injection, USP prophylaxis several days before the anticipated onset of neutropenia, and continue for 7 days after the neutrophil count rises above 1000 cells per cu mm.

Child Dose:

• Child: PO 3–12 mg/kg/day, max 600 mg/day q24h. Max 800–1,000 mg/day may be used for some CNS fungal infections.

Renal Dose:

• Renal impairment: Hemodialysis patients: Usual dose given after each session. CrCl (ml/min) Dosage Recommendation: <50 and not receiving dialysis 50% of the usual dose. >50 Usual dose.

Take Flugal 50mg Capsule as advised by your physician. Swallow the Flugal 50mg Capsule with a glass of water and do not chew or crush the medicine. The correct dose and duration for you will be decided by the doctor depending on your age, body weight, and type of infection.

✔️ Interaction

• Drug-Drug Interaction: Flugal 50mg Capsule may interact with drugs used to treat mental illness (pimozide, quetiapine), anti-depressants (reboxetine), antibiotics (erythromycin), migraine treating drugs (ergotamine), heart-related drugs (amiodarone), blood thinners (warfarin), anti-seizure medicines (carbamazepine), blood pressure-lowering agents (losartan), cholesterol-lowering drugs, and anti-diabetic drugs (metformin).
• Drug-Food Interaction: There are no specific studies indicating food interactions with Flugal 50mg Capsule. However, it is advised to consume a diet rich in non-starchy vegetables and gluten-free foods and limit alcohol and caffeine intake.
• Drug-Disease Interaction: Before taking Flugal 50mg Capsule, inform your doctor if you have a medical history of allergic reactions to medicines, heart diseases, liver or kidney problems, blood disorders like acute porphyria, and low levels of magnesium and potassium.

✔️ Contraindications

• If you are allergic to fluconazole or any other ingredient of the Flugal 50mg Capsule.
• If you are taking medicines like Astemizole, Terfenadine, Cisapride, Pimozide, Quinidine, Erythromycin.

✔️ Pregnancy & Lactation

Fluconazole is classified as a category C drug by the US Food and Drug Administration (FDA) for use during pregnancy. Fluconazole should thus be avoided during pregnancy and breastfeeding unless the potential advantages outweigh the potential hazards to the baby.

✔️ Precautions & Warnings

Before using Flugal 50mg Capsule, inform your doctor about any prescription, non-prescription medicines, including vitamin and herbal supplements you are taking. If you are allergic to Flugal 50mg Capsule or any of its components, avoid its use. Let your doctor know if you have any liver, kidney, or heart problems before starting Flugal 50mg Capsule. This medicine may not be suitable for some individuals with a weakened immune system, diabetes, cancer, or low blood magnesium or potassium levels; seek medical advice in such cases. Pregnant or lactating women should consult their doctor before taking Flugal 50mg Capsules. Avoid driving or operating machinery if you experience dizziness or other side effects that may affect your mental ability to drive. Additionally, it is advisable to avoid alcohol consumption along with Flugal 50mg Capsule to prevent undesirable effects.

✔️ Storage Conditions

Do not store Flugal 50mg Capsule above 25°C. Keep out of the reach of children and pets.